Laboratoire de Chimie Moléculaire et Thio-organique

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Dr Stéphane PERRIO

Lecturer in Organic Chemistry

Section du Comité National n° 16
Section du CNU n° 32
Tel : +33 31 45 28 84
e-mail : stephane.perrio@ensicaen.fr

Stéphane Perrio obtained his chemistry degree and also his Ph.D. at the University of Caen (1991), under the supervision of Pr. Pierre Beslin, working on a diastereoselective version of the Thio-Claisen rearrangement. In January 1992, he moved to UK as a postdoctoral research associate in the group of Dr. Susan E. Gibson (née Thomas) at Imperial College (London), where he studied arene(tricarbonyl)chromium(0) complexes possessing sulfur substituents. In September 1993, he returned to Caen to take up a lectureship in organic chemistry, where he is ever since. His research is currently carried out within the group of Pr. Annie-Claude Gaumont focussing on heteroatom chemistry.

 

Research interests

Organic synthesis, methodology, organosulfur chemistry, organocatalysis (Lewis base, phase transfer), [2.2]paracyclophane, sulfenate anion, sulfinate anion

 

Teaching

1st year Organic Chemistry for Chemists
1st year Organic Chemistry for Medicine and Pharmacy students
2nd year Special Chemistry Topics for Chemists and Physicists: introduction to 1H NMR, IR, UV and mass spectrometry
4th year Special Chemistry Topics for Chemists: mass spectrometry and introduction to 2D NMR
5thyear Special Chemistry Topics for Chemists and 3rd year of ENSICaen: NMR mediated structural determination (2D NMR, 31P and 19F NMR) and Sulfur Chemistry

Scientific records

  • 37 publications
  • 7 reviews or book chapters
  • 1 chemistry education book
  • 23 conferences

 

Key publications

Sulfinate‐Organocatalyzed (3+2) Annulation Reaction of Propargyl or Allenyl Sulfones with Activated Imines. Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière and Stéphane Perrio, Eur. J. Org. Chem., 2018, 5069-5073.  DOI: 10.1002/ejoc.201800749

Sulfinate-Organocatalyzed (3+2) Annulation of Allenyl Sulfones with 1,1-Dicyano Olefins in the Presence of a Quaternary Ammonium Phase Transfer Agent. Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière and Stéphane Perrio, Adv. Synth. Catal., 2018, 360, 2696–2706. DOI: 10.1002/adsc.201800466

Construction of Isoxazolidin-5-ones with a Tetrasubstituted Carbon Center: Enantioselective Conjugate Addition Mediated by Phase-Transfer Catalysis. Timothée Cadart, Vincent Levacher, Stéphane Perrio and Jean-François Brière, Adv. Synth. Catal., 2018, 360, 1499-1509. DOI: 10.1002/adsc.201800009

Unique Reactivity of α-Substituted Electron-Deficient Allenes using Sulfinate Salts as Lewis Base Organocatalysts. Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière, and Stéphane Perrio, Adv. Synth. Catal., 2017, 359, 96–106. DOI: 10.1002/adsc.201600929

Enantioselective Phase-Transfer Catalyzed α-Sulfanylation of Isoxazolidin-5-ones: An Entry to β2,2-Amino Acid Derivatives. Timothée Cadart, Clément Berthonneau, Vincent Levacher, Stéphane Perrio, and Jean-François Brière, Chem. Eur. J. 2016, 22, 15261–15264. DOI: 10.1002/chem.201603910

Enantiomerically Pure [2.2]Paracyclophane–4–thiol: A Planar Chiral Sulfur-based Building Block Readily Available by Resolution with an Amino Acid Chiral Auxiliary. Adrien Vincent, Damien Deschamps, Thomas Martzel, Jean-François Lohier, Christopher J. Richards, Annie-Claude Gaumont, and Stéphane Perrio, J. Org. Chem., 2016, 81, 3961–3966. DOI: 10.1021/acs.joc.6b00560

 

Book

Stéphane Perrio, Béatrice Roy, Jean-Yves Winum, Chimie – Cours, exercices et méthodes, les manuels visuels pour la licence, Fluoresciences, Dunod, June 2017. ISBN : 978-2-10-074831-0

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