Laboratoire de Chimie Moléculaire et Thio-organique

Dr Stéphane PERRIO

Lecturer in Organic Chemistry

Section du Comité National n° 16
Section du CNU n° 32

Stéphane Perrio obtained his chemistry degree and also his Ph.D. at the University of Caen (1991), under the supervision of Pr. Pierre Beslin, working on a diastereoselective version of the Thio-Claisen rearrangement. In January 1992, he moved to UK as a postdoctoral research associate in the group of Dr. Susan E. Gibson (née Thomas) at Imperial College (London), where he studied arene(tricarbonyl)chromium(0) complexes possessing sulfur substituents. In September 1993, he returned to Caen to take up a lectureship in organic chemistry, where he is ever since. His research is currently carried out within the group of Pr. Annie-Claude Gaumont focussing on heteroatom chemistry.

Research interests

Organic synthesis, methodology, organosulfur chemistry, organocatalysis (Lewis base, ion pair), [2.2]paracyclophane, sulfenate anion, sulfinate anion

Teaching

1^st year and 2^nd year Organic Chemistry for Chemists or Biologists
2^nd year Special Chemistry Topics for Chemists: introduction to ¹H NMR, IR, UV and mass spectrometry
4^th year Special Chemistry Topics for Chemists: NMR mediated structural determination (2D NMR, ³¹P and ¹⁹F NMR)
5^th year Special Chemistry Topics for Chemists and 3^rd year of ENSICaen: Sulfur Chemistry

Scientific records

38 publications
8 reviews or book chapters
4 chemistry education books
23 conferences

Key publications

Functionalization of [2.2]Paracyclophanes via a Reductive Sulfanylation Reaction. Damien Deschamps, Jean-François Lohier, Christopher J. Richards, Annie-Claude Gaumont and Stéphane Perrio, J. Org. Chem., 2021, 86, 507-514. DOI: 10.1021/acs.joc.0c02235

Sulfinate‐Organocatalyzed (3+2) Annulation Reaction of Propargyl or Allenyl Sulfones with Activated Imines. Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière and Stéphane Perrio, Eur. J. Org. Chem., 2018, 5069-5073. DOI: 10.1002/ejoc.201800749

Sulfinate-Organocatalyzed (3+2) Annulation of Allenyl Sulfones with 1,1-Dicyano Olefins in the Presence of a Quaternary Ammonium Phase Transfer Agent. Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière and Stéphane Perrio, Adv. Synth. Catal., 2018, 360, 2696–2706. DOI: 10.1002/adsc.201800466

Construction of Isoxazolidin-5-ones with a Tetrasubstituted Carbon Center: Enantioselective Conjugate Addition Mediated by Phase-Transfer Catalysis. Timothée Cadart, Vincent Levacher, Stéphane Perrio and Jean-François Brière, Adv. Synth. Catal., 2018, 360, 1499-1509. DOI: 10.1002/adsc.201800009

Unique Reactivity of α-Substituted Electron-Deficient Allenes using Sulfinate Salts as Lewis Base Organocatalysts. Thomas Martzel, Jean-François Lohier, Annie-Claude Gaumont, Jean-François Brière, and Stéphane Perrio, Adv. Synth. Catal., 2017, 359, 96–106. DOI: 10.1002/adsc.201600929

Enantiomerically Pure [2.2]Paracyclophane–4–thiol: A Planar Chiral Sulfur-based Building Block Readily Available by Resolution with an Amino Acid Chiral Auxiliary. Adrien Vincent, Damien Deschamps, Thomas Martzel, Jean-François Lohier, Christopher J. Richards, Annie-Claude Gaumont, and Stéphane Perrio, J. Org. Chem., 2016, 81, 3961–3966. DOI: 10.1021/acs.joc.6b00560

Books

Chimie organique expérimentale – l’essentiel pour l’étudiant
Stéphane Perrio, Béatrice Roy, Jean-Yves Winum, Chimie organique expérimentale – l’essentiel pour l’étudiant, collection Les Petits Experts Sciences, Dunod, août 2022. EAN : 9782100836239

Chimie – Cours, exercices et méthodes
Stéphane Perrio, Béatrice Roy, Jean-Yves Winum, Chimie – Cours, exercices et méthodes,, les manuels visuels pour la licence, 2^e édition, collection Fluoresciences, Dunod, juin 2021. ISBN : 978-2-082589-9

Chimie L1 – Je me trompe donc j’apprends !
Stéphane Perrio, Béatrice Roy, Jean-Yves Winum, Chimie L1 – Je me trompe, donc j’apprends !
Dunod, August 2020. ISBN : 978-2-10-079565-9